Sunday, July 08, 2018

Kill yourself.



Kill yourself:



Dominant at home and feared abroad, Vladimir Putin has come a long way since 2000, when he took over an ailing Russia still traumatized from the collapse of the Soviet Union a decade previously.






The history of a desperate man, a dreamer of been an emperor and not been that, but an irrational man the same as was Napoleon Bonaparte, emperor, war maker, irrational king of... no, go to the site and read the story of the suffering of the Russian people, whom are living mostly in poverty because its cities, not the rich part of it, but the poor part of it, doesn't receive the proper maintained needed care.

Most of the money of the gross national product of the Russian people is used by Vladimir Putin on warfare material to maintain an army just with the pretext: to protect Russia sovereign from been attach by other nation.

There was a time that Russia lost all its capacity to protect itself, and it was around 1992 until Putin got to manage the interest of the Russian people ...and no body intended to attack this nation at all.

...that's why Putin is more of a dreamer who behaves as an emperor as Bonaparte, invading other nations and making himself a billionaire or better said: a super-rich man while sections of many cities, towns and suburban places of Russia dies in poverty and the money taxed to its people is mostly diverted for war material not really needed while its bureaucracy of government administrators tax, illegally, anyone who goes to them for a service supposedly to get from their government and judges.

Poor people, when their suffering will stop.  It is up to them to put the limit and stop this hyena of Vladimir Putin.  I wonder: why Russian generals are so complacent to this iron irrational man of Vladimir Putin.



Infowar or whatever the name of this site is.









...Infowars or whatever the name of this site is, is the best example of what Democracy is; this is by means: only in a real, real Democracy a person could see, read and write such nefarious articles as shown and said here.  In any other type of government rather than in a Democratic Nation State, it is impossible to see such articles as seen here, and I mean it.  Go to any other region of the world and write and say or video the things said here, and you get chopped in pieces, not by a court, but by its authoritarian’s administrative people who govern the Nation State.  Just to mention some, not all because they are too many: Venezuela, China, Russia, the Philippines, Iran, Iraq, Egypt, Syria, Iran, most African nations, most Asian nations, Saudi Arabia, Yemen and the blah, blah, blah of other non-democratic Nation States. Even though, this is a nefarious site, and be it known, it is, this site as I just experience, is able to tell things that are extremely wicked and of the type of conspiracy plot to the well been of this Nation State and others around the globe such as England, Italy, France, Spain, the Dominican Republic and many other Democratic Nation State. Permit me to tell what NEFARIOUS is:  Adj.1. nefarious - extremely wicked; "nefarious schemes"; "a villainous plot"; "a villainous band of thieves “villainous wicked - morally bad in principle or practice...and that could be said only in a real Democratic Nation State as that as the USA.

Saturday, July 07, 2018

"wonder"



…some Senators wonder if they could make the big news, but they lack the talent.
“wonder”
 “An extraordinary or remarkable act or achievement

From: TheFreeDictionary, by FARLEX

https://www.youtube.com/watch?v=bOFENuFHwTk

…distinguished Senator Mr. Roskam
Have ever you driven a vehicle, which I think you have, and had you
notice that in any one of any car accident you ever had, the accident could had
been prevented.  That prevention you had realized long after the accident,
possible after arriving at you home and been with your family.  Now, would
it be fair if a police officer comes to your home and arrest you because it had been known
that that accident could had been prevented, and you did not?


See the irony of your questions here in this example given above?

...what I see here is that you are looking for a fifth leg to a cat, and a cat has only 4 legs 

...unless you see the cat's tail as a leg or something else of the cat.
...it is out of question.
Notice that this commission is doing that: looking if the cat has a fifth
leg, which just exists in the imagination of some politicians, not in smart
ones ...but the few, the least prepared to be seen by the people that elected
them as a genuine smart able politician which in real, real terms, they are
nuts.

Corruption.




Corruption.

Warning: you are entering: Vladimir Putin’s territory!

Many nations are at the bottom of progress, though they have a lot of tech, be it national or imported.  Those Nation States are almost all of Latin America and Russia.

Russia:

http://www.yamoskva.com/node/10358

Home » Blogs » evge-chesnokov's blog

Andrey Makarevich wrote an open letter to Vladimir Putin

Posted on evge-chesnokov on Tue, 07/08/2012-12:39

·        Andrey Makarevich
·        , Vladimir Putin
·        corruption
·        Moscow news

"Leader of the band" Mashina vremeni "Andrey Makarevich said that wrote an open letter to Russian President Vladimir Putin about the high level of corruption in the country, because" accumulated ". In an open letter to Makarevich, in particular, notes that over the past five to six years, "the average rollback in Russia rose by more than two to three times. The Russian authorities have recognized that corruption is one of the main problems in Russia. However, representatives of the country's leadership urged citizens to actively defend their rights in court, "RIA Novosti reported http://www.ria.ru/




"Makarevich in his letter questioned the objectivity of the judicial system in Russia, saying that "our Court today-either machine for punishing objectionable or apparatus for receiving money from the plaintiffs."

"Obviously, when it all goes to the human face, a reasonable and valid, then it is hard to keep silent," said RIA Novosti Makarevich."


"In an interview with the editors of foreign newspapers in March, Putin promised to encourage all social initiatives aimed at eradicating corruption but stated the inadmissibility of using them as a tool for political struggle. In his opinion, the situation of corruption in Russia has gradually improved, including by putting an end to the "oligarchy" and "more consistent" law enforcement actions. He assured that even higher rank does not give official immunity from prosecution for corruption offences. However, Putin said that the authorities will not arrest without sufficient proof-mass repressions in the fight against corruption would be counterproductive. The fight against corruption must become a truly national affair, rather than the subject of political speculation, populism, political exploitation, kampanejshhiny and stuffing of primitive solutions, he said."




Now, see how Vladimir Putin controls the people of Russia

He gives them a warning: don’t use that to mess around my government.  Read well what the blogger wrote above and take out the essence of the message given by that guy:  “In an interview with the editors of foreign newspapers in March, Putin promised to encourage all social initiatives aimed at eradicating corruption but stated the inadmissibility of using them as a tool for political struggle.

What do you think?

Wow! How irrisory and dumbs some politicians are.



Wow! How irrisory and dumbs some politicians are.

irrisory

(ɪˈraɪsərɪ)

adj

derisive or mocking

adj.

1. lacking intelligence or good judgment; stupid; dull-witted.

2. lacking the power of speech (offensive when applied to humans): dumb beasts of the field.

3. temporarily unable to speak: She was struck dumb with amazement.

4. refraining from speech; silent.

5. made, done, etc., without speech.

6. lacking some usual property, characteristic, etc.



From: TheFreeDictionary, By FARLEX

https://www.youtube.com/watch?v=c_fJVyQWHNE

...can't follow the questioning of the guy (a congress senator) here that contradict himself saying that someone so called Blumeng or a thing like that had business in Libya, then it is said that that man never been in Libya ...now, I question myself: if never been in Libya, how on earth was that man doing business in Libya?

...listen carefully the questions the senator asks, so fast questions are asked not waiting for proper answer, but questions after questions.  Why he doesn't wait for answers?

...means, the questions could be turned against himself and other Republicans.

Be it known that all American Secretary of States had used their own personal computers to communicate with people outside the government, for people outside the government are not accepted to enter any government's official to exchange communication for they do not work for the government, if so, then I from my computer could also exchange information with today's Secretary of State.  Only government officials do exchange info amongst them.

If I had some relation with any government official, or you the reader of this comment of mine, I would communicate with that government official via their own private computer.  Now, if I know something, I would tell something, this is: in politics, I my know something or suspect something related to terrorism; then if I am a friend of a government official, I would convey my suspicious or knowledge to that government official who, I assume, would just listen to me and from that that government official would question the FBI, or the Secret Service Or even a US general to know if the info already known is worth to pursue, if not, then ignore that info ...and that Secretary of State is not using his/her gov. computer to get that info from me, but his/her personal computer.  If any other official aside the Secretary of State think the info obtained is worth to investigate, then that gov. official would send the FBI or the CIA to listen to me and from theirs, then, initiate an investigation.  Then the thing becomes serious.  The same as if I call the police at 911 and tell of someone that I suspect killed a police officer: the police would send an officer for me to give them further data and from that data, make a former investigation.  If proven wrong, wrong it stays and is discarded.  I the data provided by me gives them some clue, the police follow that clue and make an arrest.  Thank to my info given by me. Sometime the informer is rewarded with some few hundred dollars (even with 10,000 dollars if my clue leading to the arrest of a criminal who kill a police officer).  Now, imagine if my info, instead hurt me or hurt the police officer who because of me, is able to make the investigation whether it leads to an arrest or not?  Then neither I or him would take that info as important to pursue.  And that is what this Republican Senator is doing with former Secretary of State Hillary Clinton: manipulating the situation in order to create change of opinion on "We the People..." on the mess President Donald J. Trump is doing with the Federal Government and if there is any involving from him with Russia's President.

Saturday, June 30, 2018

Here we go


Here we go: If you go and read the story by Tom Porter, it tells very clear why President Donald J. Trump is mining with fire the future of the United States of America, this is, killing the existence of this nation and its future.  Donald J. Trump is not a politician that knows to play the political game use to control the existence, at all, of the United States of America.  Donald J. Trump is a danger for US, all and for many if not all, European Union State nations, worst for Germany.  If US abandon German support, militarily, German is doom into a position of fighting against Russia just for survival, for Russia will start to erode Germany political and military status within its own citizens, German's private institution and its existence as a nation, for Russia is playing a cool manipulation of European mind in order to take, not the former territories that the Soviet Union hold long ago, Putin would control all of Europe using its energy resources Russia sells to them.  And Russia would conquer by eliminating NATO, OTAN and succeed in destroying NAFTA and any treaty of EUROPE and US with the rest of the world, Donald J. Trump its proxy to do that.  See England, away from any international unity with the rest of Europe: only Russia would be the benefited on this. The rest are losers.

…thanks to Russian’s toy President Donald J. Trump and some of the Republican Party of the USA who adore this President and don’t care for the existence of this nation, as if they would have Trump eternally as USA President …if they are not dreamers, then they are opium and marijuana consumers and I am crazed publishing this, for it might be, they are correct: first my pocket, my family and everyone else never second, for, second still my money and being on power with lies, tricking around 320 million people, for they are all stupid but them.

People that lead democracy in USA, are abandoning their post on care of other’s newcomers well inexperience, greedy and ignorant of their functions but money, money and more of it as a first resource and last resource.


Kill yourself seeing what’s going on in USA.

Human Children, AI, Space Force


Things to work on.

Human Children

Kuiper Belt.

Earth core about the size of the moon with a temp of about 12,000-16,000 degrees.

Earth Mantle about 1600 miles thick.

Permian extinction.

Carbon dioxide abundance in the atmosphere increased the earth temp ‘because it created an earth cover so that the temp didn’t dissipated but stay in the atmosphere.

...why US is playing the innocent child?

https://youtu.be/AVCR4M_KRyU

https://www.youtube.com/watch?v=AVCR4M_KRyU

US know very clear, that all China's doing is getting ready for the big one in 2047.

From here, they, China would have an upper hand.
US play the innocent, as we don't know why China is doing that while US take children to slot, first put in cages to make their families suffer a lot.

US looking and enforcing justice on all the Seas of China, while abusing immigrants seeking refuge away from their own people’s countries hyena.
For that, on the Sea of China, we work and ready we are.

What they didn't realized was that USA been getting ready not for the big one, but for any big one at any time, any day with whomever where ever: "Space Force", to fight any war on any place of the planet directly from outer space toward earth ground bases with superior coordination with the latest tech been slowly added to all land, sea and air bases.

…yet ready US is to take the fight, ready are we not to take refuges parent and children from abuser countries, for they don’t solve their own problem and keep abusing their owns.

China, as well as Russia have received a Chess mate kill by USA moving with strategic precision with advance modern tech ...without creating any artificial island or invading anyone else territories as did Russia not long ago.

...why US is playing the innocent Child?
Big powerful State Nations are working with AI and its citizens are feeling scared. And some other nations are passing their problems to other nations by doing nothing to solve it.

Artificial Intelligence will not compete for human jobs, instead, it will help humans by decreasing human population at which humans would then have much more resources available of which will induce to the finish of human wars against one to the other and the creation of the Humanoid New Order: Humans + chips in its organs, mostly the brain.  Natural being humans will have a very difficult existence if not having AI chips implanted inside its bodies including devices helping them doing jobs: running, lifting, and resting: the heart will be controlled together with all its body fluid, avoiding or extending life over 100 yrs.  Alzheimer illness will be a thing of the past: chips will help solve the problem as well as artificial virtual connections between neurons via wireless system by chips implanted in the human brain: quantum chips.

To be continued.

Human will feel each and everyone of us are humans with full respected lives.  No need to put people in cages for years and years or even a day, lowering down self-esteem; no need for a human killing other to take away their belongings, for, quantum chips would correct the wild animal emotion on those humans and would create a better reasoning of the other, on the other and for the other human.

One of the reason many humans turn criminal, is ignorance and lack of self-control; quantum chips preprogramed will solve that state of being when proper education had not been achieved by humans.

Some humans think that their emotions, feeling, and gust, is correct and must be fulfill yet it hurt any other human existence, destroy them and/or handicap them …those “some humans” feel it is good to let their emotions come to control others.  Dictators, criminals, mental perturbated (some) individuals then become intruders on others.  They force themselves onto others.

Nature, the universal nature, self-arraigned within itself; it didn’t use any intelligence, but just gravity itself …so did the Kuiper Belt.  It took its position in the solar system after many space chunks populated “planets” giving water to them and creating life-water consuming creatures that gave origin to humans.

Earth, this planet, got by accident a core, that remained in its liquid state that by accident too, help generate a field protecting humans to exist within its outer surface, think, reason, and live as well for many years.  The problem is: some of them think they own others or think they know what others should do and must do …they, those some of them don’t follow any rules, the feel they are the rules.

Earth and mostly all planets had evolved with a mantle that separate its surface from its melted core.  That natural organization is part of the existence of life for it preserve life in its most rudimentary existence: bacterium and fungi as well as its opposite: virus.

…and many accidental organization of outer space medium, had permitted that life could exist on places.  It is now that Artificial Intelligence is given a leap to the future without humans going through the process of natural selection; but AI is being the creation of humans themselves.

Now comes simple elements that shaped the existence of humans after going through natural selections such as carbon dioxide.  It helps shape what we are.


The problem: some of us think they can change natural selection, and by doing so, turn into criminals, abusers, and bigots.  Those were Hitler, Idi Amin, and Mao, Lenin and others such as Donald Trump, former President of the United States of America, thinking that they are natural selector of this nation …but criminals, just criminals.  Don’t think that the Kuiper Belt was not chosen to be where it is now, but random natural selection …former because this writing had been made to be read in the future and never ever children should be put in cages, as that man did with children as if they were animals to slot next as done when wild animals are in excess in the wild: hunt them, kill them, eliminate them; no …they are Human Children.  US solve any problem, but immigration ...seems as if other's children are worthless to deal with.

Traveling to outer space and starting to colonize Mars, a planet as creating the first military strategy outpost: "Space Force" ...and US creating AI, what a historical shame!
Is US creating a "Permian Extinction for immigrants as did natural selection?  

Thursday, June 21, 2018

My Congrats, President Donald J. Trump on this new venture for humankind.


My Congrats, President Donald J. Trump on this new venture for humankind.


Give to Caesar what belongs to Caesar and God what belongs to God …and that’s why my congratulation to him.
https://www.youtube.com/watch?v=GrzhdN4nLx8

Once upon a time On Human Evolution


Thursday, October 28, 2010

2:06 PM

Once upon a time there were many nations, some if not most, were democracies, others were communists and others socialist nation states.

Others were just pure dictatorships tending to be one or the other of the above social systems.



To be continued.

 


The end of United States of America and all its Allies as unique Democratic Nation States and leaders of this World.


Year 2047, October 21-27: last War World Third.


Plot


Human history.

The Human Race evolved few hundreds thousands years ago and ended in  the year After Christ was born, year One (1) of the first Century and ending on 2047, October 21-27 with the human civilization-technological adventures.

…with a world holocaust.

Dinosaurs were the first large animals that ended in a holocaust of which there were no vestige left of how and why they died.  It was Climate Change that killed them all at once …but humans, the so-call Homo sapiens sapient, destroyed themselves with their inventions and discoveries: the NUCLEAR BOMB.

Hope this prelude would be good enough for you to comprehend what humans did.  

Human evolution.

Animals on Plannet Earth, earthly animals.

Animals and food: Animal needs: Variety of animal with its center part, as others and humans.

Myths, Religions, System of Governments and Human behaviors, Human needs, Human Psychology.

Work on this, just to present animal movement on Plannet Earth.


  1. Protocol
  2. Underworld
  3. Assyrian
  4. Agricultural societies
  5. Feudal societies
  6. Monarchs
  7. Kings
  8. Empires
  9. Deities
  10. Gods
  11. Gods
  12. Roman society
  13. Dictatorship
  14. Colonizer
  15. Conquerors
  16. Communists
  17. Socialists
  18. Free world
  19. Deaths and myths
  20. Latino
  21. Spaniards
  22. Anglos
  23. Saxon
  24. Celts
  25. Legends
  26. Dialogue
  27. Nonsensical
  28. Religious
  29. Ethic
  30. Things
  31. Reason
  32. Death
  33. Sex
  34. Infinite
  35. Athens

Who are us

1. Protocol
Human needs are or have been engraved in their Dioxide Ribonucleic Acids so-call DNA.  Their basic needs and things have been created by the natural environment of Planet Earth before it turned into a Plannet (it is substance polluted by reasonable animals with some form of intelligence acquired via self-teaching or learning).Humans are basically based on myths: they tend to adore kings and Princess, Gods and gods as well as lies and the search for the TRUTH and create a "TRUTH" based on their needs…many don't, they follow knowledge.


Reasoning evolved in Humans since it turned from its basic root: Hominids (great apes) into Homo.
Like this: Hominoidea mutated into two (2) different groups: Hominidae and Hylobatidae did not create any subfamily and then tribes.  The one of Hominidae had further mutants, they were: the subfamily of Homininae and a different one, the subfamily of Ponginae.

Thought around millions of years those family had further mutations: the Homininae, it mutated and gave rise to two (tribes), the Hominini tribe and the Gorillini tribe.  Natural selection, created by the environment, since the first prokaryotes, via mutations created out of the Hominini two genus: The Homo genus and the Pan genus.  Notice that the family branch of the Hominidae, the Ponginae, did not develop via natural selection on mutations, into a tribe, it went into the pongo genus …a tribe is a group of homogeneous type of animals that associate amongst themselves in order to storage and/or share food, protection and shelter.  Those Hominoidea that mutated onto Hominidae to Homininae then to Hominini and finally into Homo, by logic had to be much more abundance in population than any other group that went from Homininae into Gorillini tribe that ended into the Gorilla which were much abundant than the Hominoidea superfamily via natural selection, and still existed at the same time, this is, those that mutated and were better fittest for survival thanks to the recombination of their Dioxide Ribonucleic Acids (DNA), the Hominidae.  The least fitted became the Hylobatidae family ending in four (?) genera of genus that could not survive the environment on the time.  Notice that those that better fitted to the environment, had a larger brain size than any of their antecedent Hominoidea …brain activity developed which in turn created much brain neurons in the brain cavity due to the chosen environment, those of which their brain mutated (by accident), were capable to live in the changing environment at a better position than those that did not.  So, survival of the fittest gave advantages for the ones with more neurons to adapt and reproduce, so to control resources on their advantageous needs and use, and controlling the ones with least brain neuron: differing in survival of the fittest.

Brute wild strength was substituted by increasingly brain ability into slowly acquired reasoning via DNA recombination; this adapted Hominini descendants of the Homo tribes to grow in larger population with larger brain size, and therefore large tribes in reference to its members resulting in better protection against environmental hazards and natural phenomena, turning the Hominini Homo weaker but smarter than The Pan genus and still the Gorilla and the Pongo genus.  This is, survival of the fittest at work.  So, their brains developed slightly different, it varied due to adaptation: Known Homo brain seen from underneath. 


https://en.wikipedia.org/wiki/Pongidae


 different frontal pole in Homo than in Pan, Gorilla and Pongo; their olfactory track: in Homo’s shortened while the length of the olfactory track of the Pan, Gorilla and Pongo were a little larger, which could be deducted by seen the shape of their faces, it shortened less.  This created different head structure in different tribes.  It is not known if these tribes mixed, this is, if they interbreed; but if we compare actual skulls from the Mongol of Asia against skulls of Western people (actual human heads) will notice the following: differs in the roundness of the face when view in its natural alive shape.



 Distinction to hominins[edit source]


Pongids
Humans[notes 1]
Mode of locomotion
Location of foramen magnum
Back of the skull
Under the skull
Average brain capacity
400 cc
1700 cc
Skull (viewed from top)
pear-shaped
ovoid
Widest part of skull viewed from behind
Parietal region
Base of the skull(near the auditory region)
Palate
Rectangular
Parabolic
Body Growth
Fast
Slow
Curved
Straight



The Mongol people skull’s is widest from the parietal region than the Western skull that is wider at its base (near the auditory region).  This differentiation is much clear between Pongids and Humans skulls as noticed above “Distinction to hominins”.  Meaning this: Homininae and Ponginae were not yet different species but a variety one from the other on the steps of evolution toward acquiring different set of DNA strands via natural selection in process due to different environment through millions of years.  As the environment changed, so did their brain bio.  Those Hominidae Homininae kept differing from the Hominidae Ponginae until converting into different genus of the same species and further into different variety: the Australopithecine that include the Australopithecus and Paranthropus genera as well as the Kenyanthropus, Ardipithecus and Praeanthropus (related species) very close relative of the Hominini.

Australopithecines:  







Homo ("humans")
Temporal range: Piacenzian-Present, 2.865–0 Ma
O
S
D
C
P
T
J
K
N

e

Kingdom:
Phylum:
Class:
Order:
Suborder:
Infraorder:
Family:
Subfamily:
Tribe:
Genus:
Homo

Linnaeus, 1758


other species or subspecies suggested


    Synonyms[hide]
    • Africanthropus Dreyer, 1935
    • Atlanthropus Arambourg, 1954
    • Cyphanthropus Pycraft, 1928
    • Pithecanthropus Dubois, 1894
    • Protanthropus Haeckel, 1895
    • Sinanthropus Black, 1927
    • Tchadanthropus Coppens, 1965
    • Telanthropus Broom & Anderson 1949



e






















From <https://d.docs.live.net/ec8ee9b1503b6ac6/MyWorkspace%20Editing%20Room-MyEspacioDeTrabajo%20Cuarto%20de%20Edición/Animals%20on%20Plannet%20Earth%5e.docx>

Origin of Life:






New research shows that the close linkage between the physical properties of amino acids, the genetic code, and protein folding was likely the key factor in the evolution from building blocks to organisms in Earth's primordial soup. Credit: Gerald Prins

In the beginning, there were simple chemicals. And they produced amino acids that eventually became the proteins necessary to create single cells. And the single cells became plants and animals. Recent research is revealing how the primordial soup created the amino acid building blocks, and there is widespread scientific consensus on the evolution from the first cell into plants and animals. But it's still a mystery how the building blocks were first assembled into the proteins that formed the machinery of all cells. Now, two long-time University of North Carolina scientists - Richard Wolfenden, PhD, and Charles Carter, PhD - have shed new light on the transition from building blocks into life some 4 billion years ago.

"Our work shows that the close linkage between the physical properties of amino acids, the genetic code, and protein folding was likely essential from the beginning, long before large, sophisticated molecules arrived on the scene," said Carter, professor of biochemistry and biophysics at the UNC School of Medicine. "This close interaction was likely the key factor in the evolution from building blocks to organisms."

Their findings, published in companion papers in the Proceedings of the National Academy of Sciences, fly in the face of the problematic "RNA world" theory, which posits that RNA - the molecule that today plays roles in coding, regulating, and expressing genes - elevated itself from the primordial soup of amino acids and cosmic chemicals to give rise first to short proteins called peptides and then to single-celled organisms.

Wolfenden and Carter argue that RNA did not work alone; in fact, it was no more likely that RNA catalyzed peptide formation than it was for peptides to catalyze RNA formation.

The finding adds a new layer to the story of how life evolved billions of years ago.

Its name was LUCA

The scientific community recognizes that 3.6 billion years ago there existed the last universal common ancestor, or LUCA, of all living things presently on Earth. It was likely a single-cell organism. It had a few hundred genes. It already had complete blueprints for DNA replication, protein synthesis, and RNA transcription. It had all the basic components - such as lipids - that modern organisms have. From LUCA forward, it's relatively easy to see how life as we know it evolved.

Before 3.6 billion years, however, there is no hard evidence about how LUCA arose from a boiling caldron of chemicals that formed on Earth after the creation of the planet about 4.6 billion years ago. Those chemicals reacted to form amino acids, which remain the building blocks of proteins in our own cells today.

"We know a lot about LUCA and we are beginning to learn about the chemistry that produced building blocks like amino acids, but between the two there is a desert of knowledge," Carter said. "We haven't even known how to explore it."

The UNC research represents an outpost in that desert.

"Dr. Wolfenden established physical properties of the twenty amino acids, and we have found a link between those properties and the genetic code," Carter said. "That link suggests to us that there was a second, earlier code that made possible the peptide-RNA interactions necessary to launch a selection process that we can envision creating the first life on Earth."

Thus, Carter said, RNA did not have to invent itself from the primordial soup. Instead, even before there were cells, it seems more likely that there were interactions between amino acids and nucleotides that led to the co-creation of proteins and RNA.

Complexity from simplicity

Proteins must fold in specific ways to function properly. The first PNAS paper, led by Wolfenden, shows that both the polarities of the twenty amino acids (how they distribute between water and oil) and their sizes help explain the complex process of protein folding - when a chain of connected amino acids arranges itself to form a particular 3-dimensional structure that has a specific biological function.

"Our experiments show how the polarities of amino acids change consistently across a wide range of temperatures in ways that would not disrupt the basic relationships between genetic coding and protein folding," said Wolfenden, Alumni Distinguished Professor of Biochemistry and Biophysics. This was important to establish because when life was first forming on Earth, temperatures were hot, probably much hotter than they are now or when the first plants and animals were established.

A series of biochemical experiments with amino acids conducted in Wolfenden's lab showed that two properties - the sizes as well as the polarities of amino acids - were necessary and sufficient to explain how the amino acids behaved in folded proteins and that these relationships also held at the higher temperatures of Earth 4 billion years ago.

The second PNAS paper, led by Carter, delves into how enzymes called aminoacyl-tRNA synthetases recognized transfer ribonucleic acid, or tRNA. Those enzymes translate the genetic code.

"Think of tRNA as an adapter," Carter said. "One end of the adapter carries a particular amino acid; the other end reads the genetic blueprint for that amino acid in messenger RNA. Each synthetase matches one of the twenty amino acids with its own adapter so that the genetic blueprint in messenger RNA faithfully makes the correct protein every time."

Carter's analysis shows that the two different ends of the L-shaped tRNA molecule contained independent codes or rules that specify which amino acid to select. The end of tRNA that carried the amino acid sorted amino acids specifically according to size.

The other end of the L-shaped tRNA molecule is called the tRNA anticodon. It reads codons, which are sequences of three RNA nucleotides in genetic messages that select amino acids according to polarity.

Wolfenden and Carter's findings imply that the relationships between tRNA and the physical properties of the amino acids - their sizes and polarities - were crucial during the Earth's primordial era. In light of Carter's previous work with very small active cores of tRNA synthetases called Urzymes, it now seems likely that selection by size preceded selection according to polarity. This ordered selection meant that the earliest proteins did not necessarily fold into unique shapes, and that their unique structures evolved later.

Carter said, "Translating the genetic code is the nexus connecting pre-biotic chemistry to biology."

He and Wolfenden believe that the intermediate stage of genetic coding can help resolve two paradoxes: how complexity arose from simplicity, and how life divided the labor between two very different kinds of polymers: proteins and nucleic acids.

"The fact that genetic coding developed in two successive stages - the first of which was relatively simple - may be one reason why life was able to emerge while the earth was still quite young," Wolfenden noted.

An earlier code, which enabled the earliest coded peptides to bind RNA, may have furnished a decisive selective advantage. And this primitive system could then undergo a natural selection process, thereby launching a new and more biological form of evolution.

"The collaboration between RNA and peptides was likely necessary for the spontaneous emergence of complexity," Carter added. "In our view, it was a peptide-RNA world, not an RNA-only world."